MicroTissue Lab


Prof. Yaakov Nahmias

Our work weaves tissue engineering and microfluidics to study how cells process information under dynamic physiological conditions. We study the metabolic regulation of infection, human development, tissue morphogenesis and organ regeneration. Applications range from faster drug development and personalized medicine, to animal-free toxicity studies and cultured meat.  

Yaakov "Koby" Nahmias is an ERC-funded biomedical engineer and innovator. He is the founding director of the Alexander Grass Center for Bioengineering and adjunct faculty at Harvard Medical School. Nahmias won the Golda Meir Lectureship Award in 2011, the prestigious Rappaport Prize in Biomedical Research in 2014 and the Kaye Innovation Award in 2018. In 2017 he became the first scientist outside Britain to win the Rosetrees Trust Interdisciplinary Prize for his pioneering work on liver-on-chip.

Nahmias is a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and the British Royal Society of Medicine (RSM). He is an editorial board member of the Annual Reviews for Biomedical Engineering, and a long-standing member of the European Research Council grant committee.



Selected Publications

  • A. Ehrlich, D. Duche, G. Ouedraogo, Y. Nahmias,  Challenges and Opportunities in the Design of Liver-on-Chip Microdevices. Annu Rev Biomed Eng. 2019 Jun 4;21:219-239.
  • A. Ehrlich, M. Ayyash, M. Cohen, S. Tsytkin-Kirschenzweig, K. Ioannidis, A. Riu, R. Note, G. Ouedraogo, G. Vanfleteren, Y. Nahmias, Microphysiological flux balance platform unravels the dynamics of drug induced steatosis. Lab Chip. 2018 Aug 21;18(17):2510-2522.
  • E. Keinan, A.C. Abraham, A. Cohen, A.I. Alexandrov, R. Mintz, M. Cohen, D. Reichmann, D. Kaganovich, Y. Nahmias, High-Reynolds Microfluidic Sorting of Large Yeast Population Demonstrates Early Age-Dependent Changes in Protein Quality Control. Sci Rep. 2018 Sep 13;8(1):13739

  • G. Levy, M.A. Guzzardi, N. Habib, D. Kitsberg, D. Bomze, B.E. Uygun, K. Uygun, M. Trippler, J.F. Schlaak, O. Shibolet, E.H. Sklan, M. Cohen, J. Timm, N. Friedman, Y. Nahmias, Nuclear Receptors Control Pro- and Anti-Viral Metabolic Response to HCV Infection. Nat Chem Biol. 2016 Dec;12(12):1037-1045
  • D. Bavli, S. Prill, E. Ezra, G. Levy, M. Cohen, M. Vinken, J. Vanfleteren, M. Jaeger, Y. Nahmias, Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction. PNAS 113(16):E2231-40. (2016)
  • G. Levy, D. Bomze, S. Heinz, S.D. Ramachandran, A. Noerenberg, M. Cohen, O. Shibolet, E. Sklan, J. Braspenning, Y. Nahmias. Long-term culture and expansion of primary human hepatocytes. Nature Biotechnology 33(12): 1264-1271. (2015)
  • B. Uygun, A. Soto-Gutierrez, H. Yagi, M.L. Izamis, M.A. Guzzardi, C. Shulman, J. Milwid, N. Kobayashi, A. Tilles, F. Berthiaume, M. Hertl, Y. Nahmias, M.L. Yarmush, K. Uygun. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nature Medicine. 16(7):814-20. (2010)